Results from the study using liquid biopsy to detect copy number variations (CNVs), especially PTEN copy number loss, are now published in JCO Precision Oncology.
Predicine, Inc. today announced results from a prostate cancer liquid biopsy study evaluating the landscape of genomic alterations in 231 patients with metastatic castration-resistant prostate cancer (mCRPC) from US and Australian cohorts.
The study demonstrated the robust sensitivity and clinical utility of Predicine’s cfDNA liquid biopsy assay for detecting CNVs in the PTEN-PI3K-AKT pathway in mCRPC patients. It also found that concurrent CNVs in the PTEN-PI3K-AKT and AR pathways portend poor survival, and identifying this high-risk patient subset for dual AR/Akt inhibition may optimize precision treatment with Akt inhibitors. The study, “Plasma Cell-Free DNA Profiling of PTEN-PI3KAKT Pathway Aberrations in Metastatic Castration-Resistant Prostate Cancer,” was published online in JCO Precision Oncology, a journal of American Society of Clinical Oncology.
Metastatic prostate cancer is characterized by recurrent gene copy gains and deletions. In particular, PTEN copy number loss is found in 40-60% of the patients. PTEN status is often measured using tissue biopsy. However, blood-based non-invasive detection of PTEN loss has historically been challenging, thus representing an unmet medical need for patient care and clinical drug development. This study showed that using the Predicine cfDNA liquid biopsy assay, plasma cfDNA can be used to determine copy number status in mCRPC and may be a highly valuable tool for identifying millions of patients suitable for precision treatment with PTEN-PI3K-AKT pathway inhibitors.
“The use of liquid biopsy to detect PTEN copy number loss in mCRPC helps facilitate and optimize patient selection for targeted treatment with Akt inhibitors in mCRPC,” said Dr. Shidong Jia, Founder and CEO at Predicine. “With Predicine’s next-generation liquid biopsy platform to decipher genomic insights especially gene deletion, we are able to identify nearly half of the prostate cancer patients that may benefit from targeted therapy. Predicine was founded to address this unmet medical need. No patients should be left behind.”
The publication can be found online at: https://www.predicine.com/publications/
Official press release can be found: (Here)